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The trials demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo

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In contrast, when utilising 30% U- 13 CR 6 -labelled arginine as the sole carbon source, there were only a few differences between the metabolic labelling in gdh3 / gdh3 and wild-type cells that included two TCA cycle intermediates (fumarate and cis -aconitate) and all three aromatic amino acids (phenylalanine, tryptophan, and tyrosine)